Ingredient

Isopropyl Cloprostenate

Isopropyl Cloprostenate is flagged for pregnancy, trying to conceive, breastfeeding, postpartum, PCOS and general use. The concern behind the strongest flag is hormone disruptor and absorbed into the body.

By Team TruvaLast checked

Verdict by profile

Truva checks every ingredient against six profiles. Jump to any of them for the full assessment.

Strongest verdict
Not Recommended
Its verdict for pregnancy, the profile this one is worst in
Profiles flagged
6 of 6
Counting avoid, high risk and medium risk
Irritancy
2 of 5
Higher means more likely to sting or redden
PregnancyAVOID

Isopropyl Cloprostenate and pregnancy

Not Recommended

Isopropyl Cloprostenate is a synthetic prostaglandin analog used in eyelash serums to enhance lash growth. Prostaglandins are hormone-like substances that play crucial roles in reproductive processes, including labor initiation and cervical ripening. According to medical literature, prostaglandin analogs can trigger uterine contractions and are medically used to induce labor or manage miscarriages. While topical ophthalmic use has lower systemic absorption than oral forms, any systemic exposure during pregnancy carries theoretical risks of preterm labor or fetal effects. The FDA has not approved cosmetic prostaglandin analogs for use during pregnancy, and pharmaceutical prostaglandins carry pregnancy warnings. ACOG and most obstetricians recommend avoiding all prostaglandin-containing products during pregnancy due to their potent effects on the uterus and reproductive system. The risk-benefit analysis for a cosmetic enhancement strongly favors avoidance during all trimesters.

BreastfeedingAVOID

Isopropyl Cloprostenate and breastfeeding

Not Recommended

Prostaglandin analogs are fat-soluble compounds that can potentially transfer into breast milk. While specific data on isopropyl cloprostenate in breastfeeding is lacking, pharmaceutical prostaglandins are known to be secreted in breast milk and can affect infants. The concern centers on potential infant exposure to a hormone-like substance during a critical developmental period. Prostaglandins affect multiple physiological systems, and infant exposure through breast milk has not been adequately studied for cosmetic prostaglandin analogs. Most pediatricians and dermatologists recommend avoiding prostaglandin-containing cosmetics while breastfeeding due to unknown safety profiles and the availability of safer alternatives for cosmetic enhancement.

PostpartumCAUTION

Isopropyl Cloprostenate and postpartum

Caution Advised

For postpartum women not breastfeeding, isopropyl cloprostenate presents fewer concerns than during pregnancy or breastfeeding, but caution is still warranted. The postpartum period involves significant hormonal adjustments as the body returns to pre-pregnancy states. While there are no absolute contraindications for non-breastfeeding postpartum use, the lack of safety data combined with the ingredient's hormone-like activity suggests a conservative approach. Women may choose to wait until hormonal balance is reestablished (typically 3-6 months postpartum) before using prostaglandin-containing cosmetics.

Trying to ConceiveAVOID

Isopropyl Cloprostenate and trying to conceive

Not Recommended

Women trying to conceive should avoid isopropyl cloprostenate due to prostaglandins' direct role in reproductive processes. Prostaglandins are involved in ovulation, implantation, and early pregnancy maintenance, and introducing synthetic analogs could theoretically interfere with these delicate processes. Fertility specialists typically recommend discontinuing prostaglandin-containing cosmetics when actively trying to conceive, applying the same precautionary principle used for known teratogens. Since you may become pregnant before realizing it, avoidance during the TTC period provides a safety margin for the critical early weeks of fetal development.

PCOSCAUTION

Isopropyl Cloprostenate and PCOS

Caution Advised

Women with PCOS already experience hormonal imbalances involving androgens, insulin, and reproductive hormones. Isopropyl cloprostenate, as a prostaglandin analog, has hormone-like activity that theoretically could interact with the already dysregulated hormonal environment in PCOS. No specific studies have examined prostaglandin analogs in cosmetics and PCOS outcomes. However, because PCOS management often involves careful hormonal balance, introducing exogenous hormone-like substances requires consideration. Most endocrinologists would likely recommend discussing cosmetic prostaglandin use with your healthcare provider if you have PCOS, particularly if you're on hormonal treatments or trying to conceive. Safer lash enhancement alternatives exist that don't involve hormone-like mechanisms.

General UseCAUTION

Isopropyl Cloprostenate and general use

Caution Advised

For the general public, isopropyl cloprostenate is used in eyelash enhancement products and can be effective for promoting lash growth. However, prostaglandin analogs are associated with side effects even in healthy adults. Common side effects reported in cosmetic use include eye irritation, redness, itching, and darkening of eyelid skin. More concerning are reports of iris color changes (especially in lighter-colored eyes), orbital fat loss leading to sunken eyes, and permanent hyperpigmentation. These effects may be irreversible even after discontinuing use. The FDA has issued warnings about prostaglandin analogs in cosmetics, and some formulations have faced regulatory scrutiny. Users should be aware of potential side effects and consider whether cosmetic enhancement justifies these risks when safer alternatives exist.

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Provenance

Where this came from

Truva summarises published guidance from bodies including ACOG, the FDA, the EU SCCS and the Cosmetic Ingredient Review. It has no access to your medical history and it is not a substitute for your doctor, dermatologist or midwife. These assessments have not been reviewed by a clinician, and nothing here is a diagnosis or a prescription. If you are pregnant, breastfeeding or being treated for PCOS, take the ingredient list to the person looking after you.

Assessment last pulled from the ingredient database on .

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