Ingredient
CI 12245
CI 12245 is flagged for pregnancy and trying to conceive. The concern behind the strongest flag is absorbed into the body.
- Acid Orange 67
- C.I. 12245
- Pigment Orange 34
Verdict by profile
Truva checks every ingredient against six profiles. Jump to any of them for the full assessment.
- Strongest verdict
- Caution Advised
- Its verdict for pregnancy, the profile this one is worst in
- Profiles flagged
- 2 of 6
- Counting avoid, high risk and medium risk
- Irritancy
- 2 of 5
- Higher means more likely to sting or redden
CI 12245 and pregnancy
Caution Advised
- Absorbed into the body
CI 12245 is a synthetic azo dye used primarily for coloring cosmetic products orange. While colorants are typically applied topically, azo dyes belong to a chemical class that has raised some reproductive health concerns due to potential breakdown products. Specific pregnancy safety data for CI 12245 is limited. Azo dyes as a class have shown varied toxicity profiles, and some can be absorbed through skin, particularly when applied to damaged or compromised skin barriers. While most cosmetic colorants have minimal systemic absorption, the lack of robust pregnancy-specific studies means their effects on fetal development haven't been fully characterized. Most dermatologists and obstetricians recommend pregnant women use products with well-studied ingredients when possible. While CI 12245 isn't explicitly prohibited during pregnancy, the limited safety data and potential for skin absorption warrant a cautious approach. Many women choose to minimize exposure to synthetic dyes during pregnancy, particularly in leave-on products or those applied to large body areas.
CI 12245 and breastfeeding
Safe to Use
CI 12245 is used as a colorant in cosmetics and is typically applied topically in finished products. When used in makeup or hair products, systemic absorption is generally minimal, and the likelihood of transfer to breast milk is low. There are no specific studies on CI 12245 and breastfeeding, but topical colorants in cosmetics are generally considered low concern for breastfeeding mothers. The molecular structure and typical use patterns suggest limited penetration into the bloodstream and minimal risk of accumulation in breast milk. Most dermatologists consider cosmetic colorants safe during breastfeeding when used in conventional products like makeup and hair dye. However, breastfeeding women should ensure products aren't applied directly to the breast area before breastfeeding to prevent infant oral exposure.
CI 12245 and postpartum
Safe to Use
For postpartum women who are not breastfeeding, CI 12245 poses minimal health concerns when used in typical cosmetic formulations. The primary considerations are the same as for the general population: potential for allergic reactions or skin irritation in sensitive individuals. Postpartum skin can be more sensitive due to hormonal changes, so patch testing new products containing colorants like CI 12245 is advisable. However, there are no specific postpartum contraindications for this ingredient beyond general skin sensitivity considerations.
CI 12245 and trying to conceive
Caution Advised
- Absorbed into the body
CI 12245 is a synthetic azo dye used in cosmetics. For women trying to conceive, the lack of comprehensive reproductive toxicity data creates some uncertainty. While not proven harmful, many healthcare providers recommend minimizing exposure to ingredients with limited safety profiles during the preconception period. The principle of preconception care involves optimizing health before pregnancy, which often includes reducing exposure to chemicals with unknown effects on fertility or early fetal development. While CI 12245 isn't classified as a reproductive toxin, the limited data means it falls into a category where cautious women may choose alternatives. Most fertility specialists focus on known endocrine disruptors, and synthetic dyes aren't typically priority concerns, but individual tolerance for uncertainty varies.
CI 12245 and PCOS
Safe to Use
CI 12245 is a synthetic colorant with no known hormonal activity or impact on androgen levels, insulin sensitivity, or other metabolic factors relevant to PCOS. Women with PCOS can safely use products containing this ingredient. The primary concern for women with PCOS would be the same as for the general population: potential skin irritation, particularly if PCOS-related skin sensitivity or inflammatory acne is present. However, the colorant itself doesn't interact with PCOS pathophysiology. Women with PCOS who experience heightened skin sensitivity may want to patch test products with synthetic dyes, but there's no medical reason to avoid CI 12245 specifically due to PCOS.
CI 12245 and general use
Safe to Use
- Common allergen
- Irritant
CI 12245 is a synthetic azo dye approved for use in cosmetics as an orange colorant. It's found in various makeup products, hair dyes, and nail polishes where vibrant orange tones are desired. The ingredient serves purely aesthetic purposes with no therapeutic benefits. The primary concern with CI 12245 is potential for allergic contact dermatitis in sensitive individuals. Azo dyes as a chemical class can trigger reactions in people with dye sensitivities. Some individuals may also experience mild skin irritation, redness, or itching upon contact. People with known sensitivities to azo dyes or synthetic colorants should avoid products containing this ingredient. CI 12245 is regulated and permitted in cosmetics by both the EU and FDA, indicating it has passed basic safety assessments for topical use. However, it's restricted from certain applications like eye area cosmetics in some regions. For most people, occasional use in conventional cosmetic products poses minimal risk, but those with sensitive skin should patch test products containing this colorant.
Everything else flagged for the same profiles
Related ingredients
Ingredients suggested in place of CI 12245, each one with its own page here.
Ingredients that raise the same concerns.
Where this came from
Truva summarises published guidance from bodies including ACOG, the FDA, the EU SCCS and the Cosmetic Ingredient Review. It has no access to your medical history and it is not a substitute for your doctor, dermatologist or midwife. These assessments have not been reviewed by a clinician, and nothing here is a diagnosis or a prescription. If you are pregnant, breastfeeding or being treated for PCOS, take the ingredient list to the person looking after you.
Assessment last pulled from the ingredient database on .
One ingredient is the easy case.
A label has thirty of them. Truva reads the whole list at once and answers for the profile you set: pregnancy, breastfeeding, postpartum, trying to conceive, PCOS, or general use.
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